Bcl-2 è un gene codificato dal simbolo BCL2. È noto anche come Apoptosis regulator BCL2. Bcl-2 ha una massa di 26.27kDa e una lunghezza di amminoacidi di 239.
Offriamo 8 proteine Bcl-2
Informazioni su geni e proteine
Riepilogo UniProt
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Sommario di Entrez
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Expressed in a variety of tissues.
Somiglianze di sequenza
Belongs to the Bcl-2 family.
Modifica post-translazionale
Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Posizione cellulare
Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
