Zyxin è un gene codificato dal simbolo ZYX. È noto anche come: Zyxin-2; ZYX. Zyxin ha una massa di 61.28kDa e una lunghezza di amminoacidi di 572.
Offriamo 7 anticorpi contro Zyxin, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Sommario di Entrez
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Somiglianze di sequenza
Belongs to the zyxin/ajuba family.
Posizione cellulare
Cytoplasm. Cytoplasm > Cytoskeleton. Nucleus. Cell junction > Focal adhesion.
Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
