VGF è un gene codificato dal simbolo VGF. È noto anche come Neurosecretory protein VGF. VGF ha una massa di 67.26kDa e una lunghezza di amminoacidi di 615.
Offriamo 7 anticorpi contro VGF, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).
Sommario di Entrez
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
Specificità del tessuto
Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
Modifica post-translazionale
Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
Posizione cellulare
Secreted. Cytoplasmic vesicle > Secretory vesicle.
Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
