VEGFB è un gene codificato dal simbolo VEGFB. È noto anche come: Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF. VEGFB ha una massa di 21.6kDa e una lunghezza di amminoacidi di 207.
Offriamo 7 anticorpi contro VEGFB, allevati nel Coniglio e Human, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Sommario di Entrez
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Specificità del tessuto
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Somiglianze di sequenza
Belongs to the PDGF/VEGF growth factor family.
Modifica post-translazionale
VEGF-B186 is O-glycosylated.
Posizione cellulare
Secreted.
Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
