VCAM1 è un gene codificato dal simbolo VCAM1. È noto anche come: Vascular cell adhesion protein 1; V-CAM 1; INCAM-100. VCAM1 ha una massa di 81.28kDa e una lunghezza di amminoacidi di 739.
Offriamo 36 anticorpi contro VCAM1, allevati nel Coniglio, Topo, Capra, Ratto e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Maiale e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Sommario di Entrez
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
Specificità del tessuto
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Modifica post-translazionale
Sialoglycoprotein.
Posizione cellulare
Membrane.
