VAMP2 è un gene codificato dal simbolo VAMP2. È noto anche come: Vesicle-associated membrane protein 2; VAMP-2; Synaptobrevin-2; SYB2. VAMP2 ha una massa di 12.66kDa e una lunghezza di amminoacidi di 116.
Offriamo 6 anticorpi contro VAMP2, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Sommario di Entrez
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
Specificità del tessuto
Nervous system and skeletal muscle.
Somiglianze di sequenza
Belongs to the synaptobrevin family.
Modifica post-translazionale
Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.
Posizione cellulare
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell junction > Synapse > Synaptosome. Cell membrane.
Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651).
