uPA Receptor è un gene codificato dal simbolo PLAUR. È noto anche come: Urokinase plasminogen activator surface receptor; U-PAR; Monocyte activation antigen Mo3; PLAUR; MO3; UPAR. uPA Receptor ha una massa di 36.98kDa e una lunghezza di amminoacidi di 335.
Offriamo 2 anticorpi contro uPA Receptor, allevati nel Coniglio, che sono adatti per WB e IHC con campioni derivati da Umano e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Sommario di Entrez
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Specificità del tessuto
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Posizione cellulare
Cell membrane. Cell projection > Invadopodium membrane.
Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
