UNG è un gene codificato dal simbolo UNG. È noto anche come: Uracil-DNA glycosylase; UDG; DGU115. UNG ha una massa di 34.65kDa, una lunghezza di amminoacidi di 313, ed è implicato in Immunodeficiency with hyper-IgM 5.
Offriamo 11 anticorpi contro UNG, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Sommario di Entrez
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.
Specificità del tessuto
Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
Coinvolgimento nella malattia
Immunodeficiency with hyper-IgM 5: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
Somiglianze di sequenza
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
Modifica post-translazionale
Isoform 1 is processed by cleavage of a transit peptide.
Posizione cellulare
Mitochondrion.
