UDP glucose dehydrogenase è un gene codificato dal simbolo UGDH. È noto anche come: UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UGDH. UDP glucose dehydrogenase ha una massa di 55.02kDa e una lunghezza di amminoacidi di 494.
Offriamo 10 anticorpi contro UDP glucose dehydrogenase, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e Dot con campioni derivati da Umano, Topo, Ratto e Bovino.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).
Sommario di Entrez
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).
Somiglianze di sequenza
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
