TXNDC5 è un gene codificato dal simbolo TXNDC5. È noto anche come: Thioredoxin domain-containing protein 5; Endoplasmic reticulum resident protein 46; ER protein 46; Thioredoxin-like protein p46; TLP46. TXNDC5 ha una massa di 47.63kDa e una lunghezza di amminoacidi di 432.
Offriamo 10 anticorpi contro TXNDC5, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).
Sommario di Entrez
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene.
Somiglianze di sequenza
Belongs to the protein disulfide isomerase family.
Posizione cellulare
Endoplasmic reticulum lumen.
