TWF2 è un gene codificato dal simbolo TWF2. È noto anche come: Twinfilin-2; A6-related protein; hA6RP; Protein tyrosine kinase 9-like; Twinfilin-1-like protein; PTK9L. TWF2 ha una massa di 39.55kDa e una lunghezza di amminoacidi di 349.
Offriamo 7 anticorpi contro TWF2, allevati nel Coniglio, che sono adatti per WB, IHC e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
Sommario di Entrez
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.
Specificità del tessuto
Ubiquitously expressed (at protein level).
Somiglianze di sequenza
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
Modifica post-translazionale
In vitro, phosphorylated by PRKCZ, CK2 and SRC.
Posizione cellulare
Cytoplasm > Cytoskeleton. Cytoplasm > Perinuclear region. Cell projection > Stereocilium.
Perinuclear and G-actin-rich cortical actin structure sublocalization.
