Trypsin è un gene codificato dal simbolo PRSS1. È noto anche come: Trypsin-1; Beta-Cationic trypsinogen; Serine protease 1 I; PRSS1; TRP1; TRY1; TRYP1. Trypsin ha una massa di 26.56kDa, una lunghezza di amminoacidi di 247, ed è implicato in Pancreatitis, hereditary.
Offriamo 10 anticorpi contro Trypsin, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e Dot con campioni derivati da Umano e Bovino.
Informazioni su geni e proteine
Riepilogo UniProt
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
Sommario di Entrez
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
Coinvolgimento nella malattia
Pancreatitis, hereditary: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
Somiglianze di sequenza
Belongs to the peptidase S1 family.
Modifica post-translazionale
Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.
Posizione cellulare
Secreted > Extracellular space.
