TRIP15 è un gene codificato dal simbolo COPS2. È noto anche come: COP9 signalosome complex subunit 2; SGN2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; COPS2; CSN2. TRIP15 ha una massa di 51.6kDa e una lunghezza di amminoacidi di 443.
Offriamo 8 anticorpi contro TRIP15, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Drosofila.
Informazioni su geni e proteine
Riepilogo UniProt
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Somiglianze di sequenza
Belongs to the CSN2 family.
Modifica post-translazionale
Phosphorylated by CK2 and PKD kinases.
Posizione cellulare
Cytoplasm. Nucleus.
