Triosephosphate isomerase è un gene codificato dal simbolo TPI1. È noto anche come: TIM; Methylglyoxal synthase; Triose-phosphate isomerase; TPI1; TPI. Triosephosphate isomerase ha una massa di 30.79kDa, una lunghezza di amminoacidi di 286, ed è implicato in Triosephosphate isomerase deficiency.
Offriamo 13 anticorpi contro Triosephosphate isomerase, allevati nel Coniglio, Capra e Sheep, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e Dot con campioni derivati da Umano, Topo, Ratto, Coniglio, Cane e S. cerevisiae.
Informazioni su geni e proteine
Riepilogo UniProt
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
Sommario di Entrez
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.
Coinvolgimento nella malattia
Triosephosphate isomerase deficiency: An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy.
Somiglianze di sequenza
Belongs to the triosephosphate isomerase family.
Modifica post-translazionale
The initiator methionine for isoform 2 is removed.
Posizione cellulare
Cytoplasm.
