TRIM29 è un gene codificato dal simbolo TRIM29. È noto anche come: Tripartite motif-containing protein 29; Ataxia telangiectasia group D-associated protein; ATDC. TRIM29 ha una massa di 65.84kDa e una lunghezza di amminoacidi di 588.
Offriamo 8 anticorpi contro TRIM29, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Sommario di Entrez
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
Specificità del tessuto
Expressed in placenta, prostate and thymus.
Modifica post-translazionale
Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
Posizione cellulare
Cytoplasm. Lysosome.
Colocalizes with intermediate filaments.
