TRF1 è un gene codificato dal simbolo TERF1. È noto anche come: Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TERF1; PIN2; TRBF1; TRF. TRF1 ha una massa di 50.25kDa e una lunghezza di amminoacidi di 439.
Offriamo 12 anticorpi contro TRF1, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Sommario di Entrez
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
Specificità del tessuto
Highly expressed and ubiquitous. Isoform Pin2 predominates.
Modifica post-translazionale
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
Posizione cellulare
Nucleus. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Telomere.
Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
