Transaldolase 1 è un gene codificato dal simbolo TALDO1. È noto anche come: Transaldolase; TALDO1; TAL; TALDO; TALDOR. Transaldolase 1 ha una massa di 37.54kDa, una lunghezza di amminoacidi di 337, ed è implicato in Transaldolase deficiency.
Offriamo 9 anticorpi contro Transaldolase 1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e Dot con campioni derivati da Umano, Topo, Ratto e S. cerevisiae.
Informazioni su geni e proteine
Riepilogo UniProt
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Sommario di Entrez
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
Coinvolgimento nella malattia
Transaldolase deficiency: An inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency.
Somiglianze di sequenza
Belongs to the transaldolase family. Type 1 subfamily.
Posizione cellulare
Cytoplasm.
