TOP1MT è un gene codificato dal simbolo TOP1MT. È noto anche come DNA topoisomerase I, mitochondrial. TOP1MT ha una massa di 69.87kDa e una lunghezza di amminoacidi di 601.
Offriamo 12 anticorpi contro TOP1MT, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF e Citometria a Flusso con campioni derivati da Umano e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
Sommario di Entrez
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Specificità del tessuto
Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
Somiglianze di sequenza
Belongs to the type IB topoisomerase family.
Posizione cellulare
Mitochondrion.
