TNFRSF18 è un gene codificato dal simbolo TNFRSF18. È noto anche come: Tumor necrosis factor receptor superfamily member 18; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; AITR; GITR. TNFRSF18 ha una massa di 26kDa e una lunghezza di amminoacidi di 241.
Offriamo 17 anticorpi contro TNFRSF18, allevati nel Coniglio, Topo, Ratto e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e ChIP con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Sommario di Entrez
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Specificità del tessuto
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
Posizione cellulare
Cell membrane.
