TLR8 è un gene codificato dal simbolo TLR8. È noto anche come Toll-like receptor 8. TLR8 ha una massa di 119.83kDa e una lunghezza di amminoacidi di 1041.
Offriamo 9 anticorpi contro TLR8, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).
Sommario di Entrez
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Specificità del tessuto
Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.
Somiglianze di sequenza
Belongs to the Toll-like receptor family.
Modifica post-translazionale
Ubiquitinated by RNF216; leading to degradation by the proteasome.
Posizione cellulare
Endosome membrane.
Endosomal localization confers distinctive proteolytic processing.
