TIMP3 è un gene codificato dal simbolo TIMP3. È noto anche come: Metalloproteinase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3. TIMP3 ha una massa di 24.15kDa, una lunghezza di amminoacidi di 211, ed è implicato in Sorsby fundus dystrophy.
Offriamo 11 anticorpi contro TIMP3, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto, Bovino, Cane e Cavallo.
Informazioni su geni e proteine
Riepilogo UniProt
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Sommario di Entrez
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Coinvolgimento nella malattia
Sorsby fundus dystrophy: Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
Somiglianze di sequenza
Belongs to the protease inhibitor I35 (TIMP) family.
Posizione cellulare
Secreted > Extracellular space > Extracellular matrix.
