TIMP2 è un gene codificato dal simbolo TIMP2. È noto anche come: Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2. TIMP2 ha una massa di 24.4kDa e una lunghezza di amminoacidi di 220.
Offriamo 28 anticorpi contro TIMP2, allevati nel Coniglio, Topo e Sheep, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Coniglio, Porcellino d'India e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Sommario di Entrez
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Somiglianze di sequenza
Belongs to the protease inhibitor I35 (TIMP) family.
Modifica post-translazionale
The activity of TIMP2 is dependent on the presence of disulfide bonds.
Posizione cellulare
Secreted.
