TIGIT è un gene codificato dal simbolo TIGIT. È noto anche come: T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3. TIGIT ha una massa di 26.32kDa e una lunghezza di amminoacidi di 244.
Offriamo 17 anticorpi contro TIGIT, allevati nel Coniglio, Topo e Human, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati da Umano, Topo e Coniglio.
Informazioni su geni e proteine
Riepilogo UniProt
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Sommario di Entrez
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Specificità del tessuto
Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).
Posizione cellulare
Cell membrane.
