Thyroid Peroxidase è un gene codificato dal simbolo TPO. È noto anche come TPO. Thyroid Peroxidase ha una massa di 102.96kDa, una lunghezza di amminoacidi di 933, ed è implicato in Thyroid dyshormonogenesis 2A.
Offriamo 24 anticorpi contro Thyroid Peroxidase, allevati nel Coniglio e Topo, che sono adatti per WB e IHC con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Sommario di Entrez
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
Coinvolgimento nella malattia
Thyroid dyshormonogenesis 2A: A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Somiglianze di sequenza
Belongs to the peroxidase family. XPO subfamily.
Modifica post-translazionale
Glycosylated.
Posizione cellulare
Membrane.
