Thrombospondin 1 è un gene codificato dal simbolo THBS1. È noto anche come: Thrombospondin-1; Glycoprotein G; THBS1; TSP; TSP1. Thrombospondin 1 ha una massa di 129.38kDa e una lunghezza di amminoacidi di 1170.
Offriamo 7 anticorpi contro Thrombospondin 1, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
Sommario di Entrez
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
Somiglianze di sequenza
Belongs to the thrombospondin family.
Posizione cellulare
Secreted. Cell surface. Secreted > Extracellular space > Extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum.
Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity).
