TFPI è un gene codificato dal simbolo TFPI. È noto anche come: Tissue factor pathway inhibitor; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI1. TFPI ha una massa di 35.02kDa e una lunghezza di amminoacidi di 304.
Offriamo 10 anticorpi contro TFPI, allevati nel Coniglio, Capra e Human, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Coniglio.
Informazioni su geni e proteine
Riepilogo UniProt
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Sommario di Entrez
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Specificità del tessuto
Mostly in endothelial cells.
Modifica post-translazionale
O-glycosylated.
Posizione cellulare
Secreted.
