Tensin 1 è un gene codificato dal simbolo TNS1. È noto anche come: Tensin-1; TNS1; TNS. Tensin 1 ha una massa di 185.7kDa e una lunghezza di amminoacidi di 1735.
Offriamo 7 anticorpi contro Tensin 1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Sommario di Entrez
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specificità del tessuto
Ubiquitous.
Somiglianze di sequenza
Belongs to the PTEN phosphatase protein family.
Modifica post-translazionale
Rapidly cleaved by calpain II.
Posizione cellulare
Cell surface. Cell junction > Focal adhesion. Cytoplasm > Cytoskeleton.
Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
