TCTP è un gene codificato dal simbolo TPT1. È noto anche come: Translationally-controlled tumor protein; Fortilin; Histamine-releasing factor; HRF; p23; TPT1. TCTP ha una massa di 19.6kDa e una lunghezza di amminoacidi di 172.
Offriamo 7 anticorpi contro TCTP, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in calcium binding and microtubule stabilization.
Sommario di Entrez
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specificità del tessuto
Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.
Somiglianze di sequenza
Belongs to the TCTP family.
Posizione cellulare
Cytoplasm.
