Tbx3 è un gene codificato dal simbolo TBX3. È noto anche come T-box transcription factor T-box protein 3. Tbx3 ha una massa di 79.39kDa, una lunghezza di amminoacidi di 743, ed è implicato in Ulnar-mammary syndrome.
Offriamo 7 anticorpi contro Tbx3, allevati nel Coniglio, che sono adatti per WB, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Sommario di Entrez
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.
Specificità del tessuto
Widely expressed.
Coinvolgimento nella malattia
Ulnar-mammary syndrome: Characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.
Posizione cellulare
Nucleus.
