CD68 è un gene codificato dal simbolo CD68. Altri nomi includono: Macrosialin; Gp110. CD68 ha una massa di 37.41kDa e una lunghezza di amminoacidi di 354.
Offriamo 70 anticorpi contro CD68, allevati nel Coniglio, Topo, Capra e Ratto, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e ChIP con campioni derivati da Umano, Topo, Ratto, Bovino, Coniglio, Scimmia e Gatto.
Informazioni su geni e proteine
Riepilogo UniProt
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Sommario di Entrez
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Specificità del tessuto
Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
Somiglianze di sequenza
Belongs to the LAMP family.
Modifica post-translazionale
N- and O-glycosylated.
Posizione cellulare
Cell membrane.
