Synaptotagmin 1 è un gene codificato dal simbolo SYT1. È noto anche come: Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT1; SVP65; SYT. Synaptotagmin 1 ha una massa di 47.57kDa, una lunghezza di amminoacidi di 422, ed è implicato in Baker-Gordon syndrome.
Offriamo 9 anticorpi contro Synaptotagmin 1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Sommario di Entrez
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
Specificità del tessuto
Expressed in melanocytes (PubMed:23999003).
Coinvolgimento nella malattia
Baker-Gordon syndrome: An autosomal dominant neurodevelopmental disorder characterized by infantile hypotonia, congenital ophthalmic abnormalities, involuntary and hyperkinetic movements, stereotypic behavior, poor or absent speech, EEG abnormalities, and global developmental delay varying in severity from moderate to profound. Behavioral characteristics include sleep disturbance and episodic agitation.
Somiglianze di sequenza
Belongs to the synaptotagmin family.
Modifica post-translazionale
Glycosylated.
Posizione cellulare
Cytoplasmic vesicle > Secretory vesicle membrane. Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cytoplasmic vesicle > Secretory vesicle > Chromaffin granule membrane. Cytoplasm.
