STAT4 è un gene codificato dal simbolo STAT4. È noto anche come Signal transducer and activator of transcription 4. STAT4 ha una massa di 85.94kDa, una lunghezza di amminoacidi di 748, ed è implicato nella malattia: Systemic lupus erythematosus 11; Rheumatoid arthritis.
Offriamo 13 anticorpi contro STAT4, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Sommario di Entrez
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
Coinvolgimento nella malattia
Systemic lupus erythematosus 11: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Somiglianze di sequenza
Belongs to the transcription factor STAT family.
Modifica post-translazionale
Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Posizione cellulare
Cytoplasm. Nucleus.
Translocated into the nucleus in response to phosphorylation.
