STAM2 è un gene codificato dal simbolo STAM2. È noto anche come: Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein; HBP. STAM2 ha una massa di 58.16kDa e una lunghezza di amminoacidi di 525.
Offriamo 7 anticorpi contro STAM2, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Sommario di Entrez
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
Specificità del tessuto
Ubiquitously expressed.
Somiglianze di sequenza
Belongs to the STAM family.
Modifica post-translazionale
Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Posizione cellulare
Cytoplasm. Early endosome membrane.
