spindlin 1 è un gene codificato dal simbolo SPIN1. È noto anche come: Spindlin-1; Ovarian cancer-related protein; Spindlin1; SPIN1; OCR; SPIN. spindlin 1 ha una massa di 29.6kDa e una lunghezza di amminoacidi di 262.
Offriamo 7 anticorpi contro spindlin 1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Specificità del tessuto
Highly expressed in ovarian cancer tissues.
Somiglianze di sequenza
Belongs to the SPIN/STSY family.
Modifica post-translazionale
Phosphorylated during oocyte meiotic maturation.
Posizione cellulare
Nucleus. Nucleus > Nucleolus.
