SOX9 è un gene codificato dal simbolo SOX9. È noto anche come Transcription factor SOX-9. SOX9 ha una massa di 56.14kDa, una lunghezza di amminoacidi di 509, ed è implicato nella malattia: Campomelic dysplasia; 46,XX sex reversal 2; 46,XY sex reversal 10.
Offriamo 27 anticorpi contro SOX9, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity).
Sommario di Entrez
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
Coinvolgimento nella malattia
Campomelic dysplasia: A rare, often lethal, osteochondrodysplasia characterized by congenital bowing and angulation of long bones. Other skeletal defects include unusually small scapula, deformed pelvis and spine, and a missing pair of ribs. Craniofacial and ear defects are common. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. Up to two-thirds of affected XY individuals have genital defects or may develop as phenotypic females.
46,XX sex reversal 2: A condition in which male gonads develop in a genetic female (female to male sex reversal).
46,XY sex reversal 10: A disorder of sex development. Affected individuals have a 46,XY karyotype, show gonadal dysgenesis with streak gonads, look like normal females at birth, do not develop secondary sexual characteristics at puberty and do not menstruate.
Modifica post-translazionale
Ubiquitinated. Ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.
Posizione cellulare
Nucleus.
