Smoothened è un gene codificato dal simbolo SMO. È noto anche come: Smoothened homolog; SMO; Protein Gx; SMOH. Smoothened ha una massa di 86.4kDa, una lunghezza di amminoacidi di 787, ed è implicato in Curry-Jones syndrome.
Offriamo 6 anticorpi contro Smoothened, allevati nel Coniglio, che sono adatti per WB, ELISA e Dot con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Sommario di Entrez
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
Coinvolgimento nella malattia
Curry-Jones syndrome: A multisystem disorder characterized by patchy skin lesions, polysyndactyly, diverse cerebral malformations, unicoronal craniosynostosis, iris colobomas, microphthalmia, and intestinal malrotation with myofibromas or hamartomas.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor Fz/Smo family.
Posizione cellulare
Membrane. Cell projection > Cilium.
