Anticorpi SMC1

8 prodotti

SMC1 è un gene codificato dal simbolo SMC1A. È noto anche come: Structural maintenance of chromosomes protein 1A; SMC protein 1A; Sb1.8A; DXS423E; KIAA0178; SB1.8L1. SMC1 ha una massa di 143.23kDa, una lunghezza di amminoacidi di 1233, ed è implicato in Cornelia de Lange syndrome 2.

Offriamo 8 anticorpi contro SMC1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Sommario di Entrez
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001
Coinvolgimento nella malattia
Cornelia de Lange syndrome 2: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.
Somiglianze di sequenza
Belongs to the SMC family. SMC1 subfamily.
Modifica post-translazionale
Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.
Posizione cellulare
Nucleus. Chromosome. Chromosome > Centromere > Kinetochore.

Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis.
SMC1B antibody from Signalway Antibody (22261) - Antibodies.com
(3)
Western blot - SMC1 (Phospho-Ser966) Polyclonal Antibody from Signalway Antibody (12305) - Antibodies.com
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Anti-SMC 1 (S951) Antibody from Bioworld Technology (BS1326) - Antibodies.com
Western blot - SMC1 (Phospho-Ser957) Antibody from Signalway Antibody (11198) - Antibodies.com
(2)
Anti-SMC 1 (phospho-S957) Antibody from Bioworld Technology (BS6416) - Antibodies.com
Western blot - SMC1 (Ab-957) Antibody from Signalway Antibody (21190) - Antibodies.com
(2)
Anti-SMC 1 (phospho-S957) Antibody from Bioworld Technology (BS4174) - Antibodies.com

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