SLC25A11 è un gene codificato dal simbolo SLC25A11. È noto anche come: Mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; Solute carrier family 25 member 11; SLC20A4. SLC25A11 ha una massa di 34.06kDa, una lunghezza di amminoacidi di 314, ed è implicato in Paragangliomas 6.
Offriamo 6 anticorpi contro SLC25A11, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Acts as a tumor-suppressor gene implicated in the predisposition to metastatic paraganglioma.
Sommario di Entrez
The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992
Coinvolgimento nella malattia
Paragangliomas 6: An autosomal dominant tumor predisposition syndrome characterized by adult-onset development of paragangliomas, neural crest tumors usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Some of the tumors may secrete biologically active normetanephrine, resulting in secondary hypertension. PGL6 patients are at high risk for metastatic disease.
Somiglianze di sequenza
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Posizione cellulare
Mitochondrion inner membrane.
