Siglec 7 è un gene codificato dal simbolo SIGLEC7. È noto anche come: Sialic acid-binding Ig-like lectin 7; Siglec-7; Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; SIGLEC7; AIRM1. Siglec 7 ha una massa di 51.14kDa e una lunghezza di amminoacidi di 467.
Offriamo 14 anticorpi contro Siglec 7, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, Citometria a Flusso e IP con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Specificità del tessuto
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
Somiglianze di sequenza
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Modifica post-translazionale
Tyrosine phosphorylated.
Posizione cellulare
Membrane.
