SIAH Interacting Protein è un gene codificato dal simbolo CACYBP. È noto anche come: Calcyclin-binding protein; CacyBP; S100A6-binding protein; Siah-interacting protein; CACYBP; S100A6BP; SIP. SIAH Interacting Protein ha una massa di 26.21kDa e una lunghezza di amminoacidi di 228.
Offriamo 6 anticorpi contro SIAH Interacting Protein, allevati nel Coniglio e Topo, che sono adatti per WB, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Sommario di Entrez
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Modifica post-translazionale
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
Posizione cellulare
Nucleus. Cytoplasm.
Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
