Anticorpi SHP2

31 prodotti

SHP2 è un gene codificato dal simbolo PTPN11. È noto anche come: Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; SH-PTP3; PTPN11; PTP2C; SHPTP2. SHP2 ha una massa di 68.01kDa, una lunghezza di amminoacidi di 593, ed è implicato nella malattia: LEOPARD syndrome 1; Noonan syndrome 1; Leukemia, juvenile myelomonocytic; Metachondromatosis.

Offriamo 31 anticorpi contro SHP2, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati ​​da Umano, Topo, Ratto e Scimmia.

Informazioni su geni e proteine

Riepilogo UniProt
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Sommario di Entrez
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Specificità del tessuto
Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Coinvolgimento nella malattia
LEOPARD syndrome 1: A disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness.

Noonan syndrome 1: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints.

Leukemia, juvenile myelomonocytic: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.

Metachondromatosis: A skeletal disorder with radiologic features of both multiple exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and feet, and enchondromas of the metaphyses of long bones and iliac crest.
Somiglianze di sequenza
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Modifica post-translazionale
Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
Posizione cellulare
Cytoplasm. Nucleus.
Western Blot - Anti-SHP2 Antibody (A83775)
(5)
Western Blot - Anti-SHP2 Antibody (A14197) - Antibodies.com
(5)
Western Blot - Anti-SHP-2 Antibody (B0028) - Antibodies.com
(5)
Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-SHP-2 Antibody (B0027) - Antibodies.com
(4)
Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-SHP-2 (phospho Tyr542) Antibody (A0027) - Antibodies.com
(4)
Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-SHP2 Antibody (A93012) - Antibodies.com
(4)
Visualizza prodottoKnockout convalidato
Western Blot - Anti-SHP2 Antibody [ARC2635] (A307939) - Antibodies.com
(4)
Western Blot - Anti-SHP-2 (phospho Tyr580) Antibody (A0028) - Antibodies.com
(3)
Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-SH-PTP2 Antibody (C0321) - Antibodies.com
(2)
Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-SHP2 (phospho Tyr542) Antibody (A16556) - Antibodies.com
(3)
Segnaposto immagine Antibodies.com - Scopri di più spendendo meno
Segnaposto immagine Antibodies.com - Scopri di più spendendo meno
Western blot - SHP-2 (Ab-580) Antibody from Signalway Antibody (21320) - Antibodies.com
(3)
Western blot - SHP-2 (Ab-542) Antibody from Signalway Antibody (21319) - Antibodies.com
(3)
Western blot - SH-PTP2 Polyclonal Antibody from Signalway Antibody (41433) - Antibodies.com
(2)
Immunohistochemistry - SH-PTP2 Antibody from Signalway Antibody (33485) - Antibodies.com
(3)
Anti-SHP-2 (phospho-Y542) Antibody from Bioworld Technology (BS4170) - Antibodies.com
(2)
Western blot - SH-PTP2 Polyclonal Antibody from Signalway Antibody (41431) - Antibodies.com
(2)
Immunohistochemistry - SHP-2 (Phospho-Tyr580) Antibody from Signalway Antibody (11320) - Antibodies.com
(2)
Anti-SHP-2 (E574) Antibody from Bioworld Technology (BS1705) - Antibodies.com
(2)
Western blot - SHP-2 (Phospho-Tyr542) Antibody from Signalway Antibody (11319) - Antibodies.com
(2)
Anti-SHP-2 (S350) Antibody from Bioworld Technology (BS1323) - Antibodies.com
(2)
Western blot - PTPN11 antibody from Signalway Antibody (38468) - Antibodies.com
(2)
Western blot - SH-PTP2 (Phospho-Tyr580) Polyclonal Antibody from Signalway Antibody (12281) - Antibodies.com
Anti-SHP-2 (K536) Antibody from Bioworld Technology (BS1322) - Antibodies.com
(2)
Anti-SHP-2 Antibody from Bioworld Technology (BS7221) - Antibodies.com
(2)
Western blot - SH-PTP2 Polyclonal Antibody from Signalway Antibody (41432) - Antibodies.com
Western blot - SH-PTP2 (Phospho-Tyr542) Polyclonal Antibody from Signalway Antibody (12280) - Antibodies.com
Western blot - SHP2 Antibody from Signalway Antibody (24447) - Antibodies.com
Western blot - SHP2 Antibody from Signalway Antibody (24446) - Antibodies.com
PTPN11 Antibody from Signalway Antibody (35913) - Antibodies.com
(2)

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