SGLT1 è un gene codificato dal simbolo SLC5A1. È noto anche come: Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1; SLC5A1; NAGT. SGLT1 ha una massa di 73.5kDa, una lunghezza di amminoacidi di 664, ed è implicato in Congenital glucose/galactose malabsorption.
Offriamo 13 anticorpi contro SGLT1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto, Scimmia e Pecora.
Informazioni su geni e proteine
Riepilogo UniProt
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
Sommario di Entrez
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed mainly in intestine and kidney.
Coinvolgimento nella malattia
Congenital glucose/galactose malabsorption: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.
Somiglianze di sequenza
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Modifica post-translazionale
N-glycosylation is not necessary for the cotransporter function.
Posizione cellulare
Membrane.
