SFRP4 è un gene codificato dal simbolo SFRP4. È noto anche come: Secreted frizzled-related protein 4; sFRP-4; Frizzled protein, human endometrium; FrpHE; FRPHE. SFRP4 ha una massa di 39.83kDa, una lunghezza di amminoacidi di 346, ed è implicato in Pyle disease.
Offriamo 6 anticorpi contro SFRP4, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
Sommario di Entrez
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
Specificità del tessuto
Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
Coinvolgimento nella malattia
Pyle disease: A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.
Somiglianze di sequenza
Belongs to the secreted frizzled-related protein (sFRP) family.
Posizione cellulare
Secreted.
Cytoplasmic in ovarian tumor cells.
