Separase è un gene codificato dal simbolo ESPL1. È noto anche come: Separin; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; ESPL1; ESP1; KIAA0165. Separase ha una massa di 233.18kDa e una lunghezza di amminoacidi di 2120.
Offriamo 8 anticorpi contro Separase, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Sommario di Entrez
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009
Modifica post-translazionale
Autocleaves. This function, which is not essential for its protease activity, is unknown.
Posizione cellulare
Cytoplasm. Nucleus.
