Scavenging Receptor SR-BI è un gene codificato dal simbolo SCARB1. È noto anche come: Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; SCARB1; CD36L1; CLA1. Scavenging Receptor SR-BI ha una massa di 60.88kDa e una lunghezza di amminoacidi di 552.
Offriamo 8 anticorpi contro Scavenging Receptor SR-BI, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
Sommario di Entrez
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Widely expressed.
Somiglianze di sequenza
Belongs to the CD36 family.
Modifica post-translazionale
N-glycosylated.
Posizione cellulare
Cell membrane. Membrane > Caveola.
Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
