RRAGA è un gene codificato dal simbolo RRAGA. È noto anche come: Ras-related GTP-binding protein A; Rag A; Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1. RRAGA ha una massa di 36.57kDa e una lunghezza di amminoacidi di 313.
Offriamo 7 anticorpi contro RRAGA, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto, Criceto e Xenopus.
Informazioni su geni e proteine
Riepilogo UniProt
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:25936802). Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:20381137, PubMed:24095279, PubMed:25936802). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:25936802). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PubMed:8995684).
Specificità del tessuto
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Somiglianze di sequenza
Belongs to the GTR/RAG GTP-binding protein family.
Modifica post-translazionale
Ubiquitinated. 'Lys-68'-linked polyubiquitination of the GDP-bound inactive form of RRAGA by RNF152 is increased in response to amino acid starvation. Polyubiquitination promotes interaction with the GATOR1 complex. This does not affect RRAGA degradation.
Posizione cellulare
Cytoplasm. Nucleus. Lysosome.
Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684).
