RPL10 è un gene codificato dal simbolo RPL10. È noto anche come: 60S ribosomal protein L10; Laminin receptor homolog; Large ribosomal subunit protein uL16; Protein QM; Ribosomal protein L10; Tumor suppressor QM; DXS648E; QM. RPL10 ha una massa di 24.6kDa, una lunghezza di amminoacidi di 214, ed è implicato nella malattia: Autism, X-linked 5; Mental retardation, X-linked, syndromic, 35.
Offriamo 6 anticorpi contro RPL10, allevati nel Coniglio, che sono adatti per WB e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).
Sommario di Entrez
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants.
Coinvolgimento nella malattia
Autism, X-linked 5: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
Mental retardation, X-linked, syndromic, 35: A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Somiglianze di sequenza
Belongs to the universal ribosomal protein uL16 family.
Modifica post-translazionale
Citrullinated by PADI4.
