RP105 è un gene codificato dal simbolo CD180. È noto anche come: CD180 antigen; Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD180; LY64. RP105 ha una massa di 74.18kDa e una lunghezza di amminoacidi di 661.
Offriamo 10 anticorpi contro RP105, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
Sommario di Entrez
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.
Specificità del tessuto
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Somiglianze di sequenza
Belongs to the Toll-like receptor family.
Posizione cellulare
Cell membrane.
