ROR1 è un gene codificato dal simbolo ROR1. È noto anche come: Inactive tyrosine-protein kinase transmembrane receptor Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1. ROR1 ha una massa di 104.28kDa, una lunghezza di amminoacidi di 937, ed è implicato in Deafness, autosomal recessive, 108.
Offriamo 16 anticorpi contro ROR1, allevati nel Coniglio, Capra e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
Sommario di Entrez
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specificità del tessuto
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Coinvolgimento nella malattia
Deafness, autosomal recessive, 108: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Posizione cellulare
Membrane. Cell projection > Axon.
