Rhodopsin è un gene codificato dal simbolo RHO. È noto anche come: Opsin-2; RHO; OPN2. Rhodopsin ha una massa di 38.89kDa, una lunghezza di amminoacidi di 348, ed è implicato nella malattia: Retinitis pigmentosa 4; Night blindness, congenital stationary, autosomal dominant 1.
Offriamo 10 anticorpi contro Rhodopsin, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Cavallo e Mammifero.
Informazioni su geni e proteine
Riepilogo UniProt
Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).
Sommario di Entrez
The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness.
Specificità del tessuto
Rod shaped photoreceptor cells which mediate vision in dim light.
Coinvolgimento nella malattia
Retinitis pigmentosa 4: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Night blindness, congenital stationary, autosomal dominant 1: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Modifica post-translazionale
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region (By similarity). After activation by light, phosphorylated by GRK1 (in vitro) (PubMed:28524165).
Posizione cellulare
Membrane. Cell projection > Cilium > Photoreceptor outer segment.
Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
